SS-31 (50mg)

What is SS-31 (50mg)?

SS-31 (50mg), also known as Elamipretide or MTP-131, is a synthetic mitochondria-targeted tetrapeptide used in laboratory research. The peptide’s structure allows it to interact with mitochondrial membranes and influence cellular bioenergetic processes in experimental models.

• CAS Number: 736992-21-5
• Chemical Formula: C₃₂H₄₉N₉O₅
• Molecular Weight: 639.8 g/mol
• Sequence: D-Arg-dimethylTyr-Lys-Phe

SS-31 is manufactured with high purity, verified through analytical testing such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). It is studied for its potential interactions with mitochondrial membranes, particularly with cardiolipin, a lipid crucial for maintaining mitochondrial structure and function.

What are the key features of SS-31 (50mg)?

• Synthetic tetrapeptide composed of four amino acids
• Purity ≥98%, verified by HPLC and mass spectrometry
• Supplied as 50 mg lyophilized peptide in a sealed research vial
• Studied in mitochondrial signaling and cellular energy metabolism research
• For laboratory research use only

How is SS-31 (50mg) synthesized?

SS-31 (50mg) is synthesized using solid-phase peptide synthesis (SPPS), a widely used method for constructing peptides with precise amino acid sequences. During SPPS, amino acids are added sequentially to a growing peptide chain anchored to a solid support. After synthesis, the peptide undergoes purification using high-performance liquid chromatography (HPLC) to achieve high purity. The peptide’s molecular identity and structural integrity are verified using mass spectrometry (MS). The final peptide is lyophilized to improve stability during storage and transport.

What is SS-31 (50mg) being studied for? What are its possible benefits?

SS-31 (50mg) has been studied in laboratory research focused on mitochondrial biology and cellular energy metabolism. Mitochondria are responsible for producing cellular energy through oxidative phosphorylation, so peptides that interact with mitochondrial membranes are valuable in studies of cellular bioenergetics. Research areas involving SS-31 include:

• Studies of mitochondrial membrane structure and stability
• Investigations into oxidative stress and cellular metabolism
• Research on cellular energy production pathways
• Laboratory models examining cellular aging and mitochondrial dynamics

Some experimental studies suggest that mitochondria-targeted peptides may influence processes like reactive oxygen species regulation, mitochondrial efficiency, and cellular energy balance. These observations remain under investigation, and SS-31 is primarily used as a research tool for studying mitochondrial mechanisms.

How does SS-31 (50mg) work in research studies?

In research models, SS-31 (50mg) has been studied for its potential to interact with mitochondrial membranes, particularly with cardiolipin, a lipid that plays a central role in maintaining mitochondrial structure and function. This lipid component is key to regulating mitochondrial energy production and metabolic signaling. By associating with mitochondrial membranes, SS-31 may influence processes involved in cellular energy production and oxidative stress regulation. Researchers are studying how this interaction may impact mitochondrial stability and signaling pathways related to cellular metabolism. These mechanisms are still being explored in laboratory studies and have not been established as clinical outcomes.

What dosing information exists for SS-31 (50mg)?

Information about SS-31 dosing comes primarily from experimental research models. In animal studies, dosing parameters vary by experimental model and study design. Preclinical studies have reported dosing ranges in the microgram per kilogram (µg/kg) scale depending on the research model. Since SS-31 is used as a research compound, no standardized human dosing guidelines exist, and its use is restricted to laboratory research settings.

How should SS-31 (50mg) be stored and handled?

• Store under temperature-controlled conditions per laboratory protocol and certificate of analysis.
• For extended storage, follow temperature conditions specified in the product certificate of analysis.
• Protect the lyophilized peptide from light, heat, and moisture.
• Room-temperature exposure during transport is acceptable for short periods.
• Once reconstituted, store under appropriate temperature-controlled conditions per laboratory protocol for short-term use.
• Avoid repeated freeze-thaw cycles to preserve peptide integrity.
• Refer to the batch certificate of analysis for batch-specific stability data.

Where can I read more research about SS-31 (50mg)?

1. Zhu Y, Luo M, Bai X, et al. SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease. Oxid Med Cell Longev. 2022;2022:1295509. Published 2022 Jun 6. doi:10.1155/2022/1295509
2. Du X, Zeng Q, Luo Y, et al. Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction. Mitochondrion. 2024;75:101846. doi:10.1016/j.mito.2024.101846
3. Russo S, De Rasmo D, Signorile A, Corcelli A, Lobasso S. Beneficial effects of SS-31 peptide on cardiac mitochondrial dysfunction in tafazzin knockdown mice. Sci Rep. 2022;12(1):19847. Published 2022 Nov 18. doi:10.1038/s41598-022-24231-4
4. Russo S, De Rasmo D, Rossi R, Signorile A, Lobasso S. SS-31 treatment ameliorates cardiac mitochondrial morphology and defective mitophagy in a murine model of Barth syndrome. Sci Rep. 2024;14(1):13655. Published 2024 Jun 13. doi:10.1038/s41598-024-64368-y
5. Li M, Kong D, Meng L, Wang Z, Bai Z, Wu G. Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2) derivatives as potent agents to ameliorate inflammation and increase mitochondrial ATP synthesis. RSC Adv. 2024;14(41):29789-29799. Published 2024 Sep 18. doi:10.1039/d4ra05517a

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.