Sermorelin (5mg)

What is Sermorelin (5mg)?

Sermorelin (5mg) is a synthetic peptide corresponding to the first 29 amino acids of the naturally occurring growth hormone–releasing hormone (GHRH). It is often referred to as GHRH (1–29) because it is the biologically active fragment of the larger hypothalamic hormone that signals the pituitary gland in endocrine systems.

• Chemical Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
• Molecular Weight: 3357.9 g/mol
• CAS Number: 86168-78-7
• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂

Research-grade Sermorelin is typically produced with high purity, verified using analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). In laboratory research, Sermorelin has been studied in endocrine system models involving hormone signaling and pituitary regulation.

What are the key features of Sermorelin (5mg)?

• Synthetic 29–amino acid peptide fragment of GHRH
• Supplied as 5 mg lyophilized peptide in a sealed research-grade vial
• High analytical purity verified through HPLC and mass spectrometry
• Studied in endocrine signaling and growth hormone pathway research
• For laboratory research use only

How is Sermorelin (5mg) synthesized?

Sermorelin (5mg) is typically manufactured using solid-phase peptide synthesis (SPPS), a laboratory technique that allows controlled assembly of peptide chains with precise amino acid sequences. In this method, each amino acid residue is sequentially added to a growing chain attached to a solid support. After synthesis, the peptide undergoes purification through high-performance liquid chromatography (HPLC) to achieve high purity suitable for research applications. Structural verification is commonly performed using mass spectrometry (MS) and other analytical tools to confirm molecular weight and peptide integrity. The purified compound is then lyophilized, enhancing stability during storage and transportation.

What is Sermorelin (5mg) being studied for? What are its possible benefits?

In laboratory environments, Sermorelin (5mg) has been studied in research involving the growth hormone regulatory axis and endocrine signaling pathways. Because the peptide represents the active portion of growth hormone–releasing hormone, it is commonly used in experimental models examining hormone communication between the hypothalamus and pituitary gland. Research areas involving Sermorelin include:

• Endocrine signaling research
• Growth hormone regulatory pathway studies
• Pituitary gland function investigations
• Metabolic hormone signaling models
• Age-related endocrine system research

Experimental findings suggest that peptides derived from GHRH may influence hormone signaling mechanisms in endocrine tissues. These potential effects remain under investigation and are based on laboratory studies rather than confirmed therapeutic outcomes.

How does Sermorelin (5mg) work in research studies?

In experimental models, Sermorelin (5mg) is studied for its interaction with cellular systems involved in hormone signaling. As a GHRH fragment, the peptide is thought to act as a signaling molecule that communicates with endocrine tissues responsible for regulating hormone production. Sermorelin is used to investigate how hypothalamic signaling peptides influence communication between endocrine organs. Researchers study how this peptide may stimulate or modulate signaling pathways that coordinate hormone-related processes in metabolic and growth-related research models. These mechanisms are still being explored within experimental research environments.

What dosing information exists for Sermorelin (5mg)?

Studies involving Sermorelin (5mg) have been conducted in both cellular and animal research models. In vitro studies frequently examine the peptide at nanomolar to micromolar concentrations to evaluate its effects on cellular signaling pathways. Preclinical animal studies have reported experimental dosing ranges in the microgram-per-kilogram (µg/kg) range, depending on the design of the research model. Because Sermorelin is supplied as a research compound for laboratory use, no standardized human dosing guidelines exist for research-grade preparations.

How should Sermorelin (5mg) be stored and handled?

• Store under temperature-controlled conditions per laboratory protocol and certificate of analysis.
• For extended storage, follow temperature conditions specified in the product certificate of analysis.
• Protect the lyophilized peptide from light, moisture, and excessive heat.
• Once reconstituted with sterile laboratory-grade solvent, store at 2–8 °C for short-term use.
• Avoid repeated freeze-thaw cycles to preserve peptide integrity.
• Refer to the batch certificate of analysis for batch-specific stability data.

Where can I read more research about Sermorelin (5mg)?

1. National Center for Biotechnology Information. PubChem Compound Summary for CID 16132413, Sermorelin. https://pubchem.ncbi.nlm.nih.gov/compound/Sermorelin
2. Müller EE, Locatelli V, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev. 1999 Apr;79(2):511-607. doi: 10.1152/physrev.1999.79.2.511. PMID: 10221989.
3. Thorner MO, Vance ML, Evans WS, Blizzard RM, Rogol AD, Ho K, Leong DA, Borges JL, Cronin MJ, MacLeod RM, et al. Physiological and clinical studies of GRF and GH. Recent Prog Horm Res. 1986;42:589-640. PMID: 3090660.
4. Recinella L, Chiavaroli A, Orlando G, Ferrante C, Marconi GD, Gesmundo I, Granata R, Cai R, Sha W, Schally AV, Brunetti L, Leone S. Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice. Sci Rep. 2020 Jan 20;10(1):732. doi: 10.1038/s41598-019-57292-z. Erratum in: Sci Rep. 2020 Mar 11;10(1):4850. doi: 10.1038/s41598-020-61185-x. PMID: 31959947; PMCID: PMC6971229.

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.