Sermorelin (10mg)

What is Sermorelin (10mg)?

Sermorelin (10mg) is a synthetic peptide corresponding to the biologically active N-terminal segment of human growth hormone–releasing hormone (GHRH), commonly referenced as GHRH (1-29). It is used in laboratory research to study the somatotropic axis and mechanisms that control growth hormone (GH) secretion. Sermorelin preserves the receptor-binding domain of full-length GHRH while being easier to synthesize and handle in experimental systems.

• CAS Number: 86168-78-7
• Chemical Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
• Molecular Weight: 3357.9 g/mol
• Peptide Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂

Sermorelin has been studied for its ability to engage pituitary signaling and elicit GH release in a variety of laboratory models.

What are the key features of Sermorelin (10mg)?

• Synthetic 29-residue peptide modeling the active domain of GHRH
• 10 mg vial format suitable for pilot or repeated dosing experiments
• High purity, commonly ≥98–99%, verified by HPLC
• Identity confirmed by mass spectrometry (MS) and peptide mapping
• Used to investigate GH/IGF axis, endocrine feedback, and muscle-related signaling
• For laboratory research use only

How is Sermorelin (10mg) synthesized?

Sermorelin is produced by solid-phase peptide synthesis (SPPS), a widely used method for assembling peptides in laboratory environments. During this process, individual amino acids are sequentially attached to a solid resin until the full peptide chain is assembled. After the peptide chain is assembled, it is cleaved from the resin and deprotected. Because Sermorelin is a linear 29-residue peptide with no cysteine residues, no disulfide bond formation step is required. The crude peptide is purified by preparative HPLC, and the final product is analyzed by mass spectrometry to confirm molecular weight and peptide identity. Additional quality testing may include peptide purity analysis and verification of moisture content before release as a research reagent.

What is Sermorelin (10mg) being studied for? What are its possible benefits?

Sermorelin has been studied as a tool to probe the hypothalamic–pituitary–somatotropic axis. In preclinical work, it is used to trigger and characterize GH secretion dynamics, downstream IGF-1 responses, and endocrine feedback mechanisms. This makes it valuable for research on growth regulation, metabolism, and age-related changes in somatotropic function. Additional research areas include:

• Investigation of muscle repair and remodeling
• Metabolic signaling connected to body composition
• Comparative studies of GH pulse patterns

Preclinical observations include more physiologic GH pulsatility, measurable changes in IGF-axis markers, and altered tissue remodeling signals in controlled experimental models. These findings are model-dependent and do not imply clinical efficacy.

How does Sermorelin (10mg) work in research studies?

In experiments, Sermorelin functions as a GHRH-domain agonist at pituitary somatotrophs, initiating intracellular signaling cascades that raise cyclic AMP and promote GH synthesis and release. By administering Sermorelin, researchers can induce transient or repeated GH pulses and measure downstream signaling events such as IGF-1 production or target-tissue responses. This makes Sermorelin a useful tool for mapping the temporal dynamics of GH secretion, testing feedback loops, and studying how GH pulses influence anabolic pathways in muscle, bone, and metabolic tissues without the need for full-length hypothalamic peptides.

What dosing information exists for Sermorelin (10mg)?

Preclinical dosing in rodent models typically involves subcutaneous administration at microgram-per-kilogram doses, with dose selection depending on species, sampling interval, and study objective. Dose design should be guided by peer-reviewed preclinical protocols. No standardized human dosing guidelines exist for Sermorelin (10mg) as a research reagent.

How should Sermorelin (10mg) be stored and handled?

• Store lyophilized Sermorelin at ≤–20 °C in a tightly sealed vial, protected from light and moisture.
• Under recommended conditions, lyophilized peptides commonly remain stable for up to 24 months; confirm shelf life via the certificate of analysis.
• After reconstitution, keep solutions at 2–8 °C for short-term use and prepare aliquots to prevent repeated freeze–thaw cycles.
• Limited room-temperature exposure during shipping is typically acceptable if returned promptly to cold storage.
• Use sterile technique and low-binding labware to preserve sample integrity.

Where can I read more research about Sermorelin (10mg)?

Representative references and resources:

1. National Center for Biotechnology Information. PubChem Compound Summary for CID 16132413, Sermorelin. https://pubchem.ncbi.nlm.nih.gov/compound/Sermorelin
2. Müller EE, Locatelli V, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev. 1999;79(2):511-607. doi: 10.1152/physrev.1999.79.2.511. PMID: 10221989.
3. Thorner MO, Vance ML, Evans WS, Blizzard RM, Rogol AD, Ho K, Leong DA, Borges JL, Cronin MJ, MacLeod RM, et al. Physiological and clinical studies of GRF and GH. Recent Prog Horm Res. 1986;42:589-640. PMID: 3090660.
4. Recinella L, Chiavaroli A, Orlando G, et al. Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice. Scientific Reports. 2020;10(1):732. doi:10.1038/s41598-019-57292-z

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.