Epithalon (50mg)

What is Epithalon (50mg)?

Epithalon (50mg) is a synthetic tetrapeptide made up of four amino acids with the sequence Ala-Glu-Asp-Gly. Also known as Epitalon or Epithalone, it is classified as a short-chain regulatory peptide. This compound has been studied in laboratory models for its potential role in cellular aging research and in modulating gene expression.

Epithalon (50mg) Identification

• Chemical Formula: C₁₄H₂₂N₄O₉
• Molecular Weight: 390.34 g/mol
• CAS Number: 307297-39-8

Research-grade Epithalon is typically produced with high purity (≥95% verified by HPLC). The peptide has been studied for its involvement in telomerase-related pathways and cellular regulation. All findings are still investigational.

What are the key features of Epithalon (50mg)?

Epithalon (50mg) is supplied as a research-grade peptide for controlled laboratory use.

• High purity (≥95% verified by HPLC)
• Supplied as 50 mg of lyophilized peptide in a sealed vial
• Short tetrapeptide structure (4 amino acids)
• Studied in telomere and aging-related research models
• Shelf life of approximately 24 months under recommended storage conditions
• For laboratory research use only, intended exclusively for in vitro and preclinical applications

How is Epithalon (50mg) synthesized?

Epithalon (50mg) is synthesized using solid-phase peptide synthesis (SPPS), a method that ensures precise assembly of the four-amino-acid sequence with controlled structural integrity. After synthesis, the peptide is purified using high-performance liquid chromatography (HPLC) to achieve high purity. Analytical methods, such as mass spectrometry (MS), confirm the molecular weight and structural identity. The final product is lyophilized to improve stability during storage and handling.

What is Epithalon (50mg) being studied for? What are its possible benefits?

Epithalon (50mg) is being studied in laboratory research focusing on cellular aging and gene regulation. Investigations have explored its potential involvement in:

• Telomerase activity research
• Cell cycle regulation studies
• Oxidative stress models
• Endocrine signaling research

Epithalon has been examined for its possible effects on telomere length and age-related cellular processes. These potential biological effects remain under investigation and are based on controlled laboratory findings rather than established therapeutic outcomes.

How does Epithalon (50mg) work in research studies?

Epithalon (50mg) is being studied for its potential to interact with genetic and cellular signaling pathways. Early data suggest that it may influence gene expression related to telomerase activation and cellular replication in certain laboratory models. In simple terms, Epithalon is thought to act as a regulatory peptide that could modulate cellular mechanisms linked to aging. These mechanisms are under investigation in vitro and in animal models, and remain experimental.

What dosing information exists for Epithalon (50mg)?

Preclinical studies involving Epithalon have primarily been conducted in animal models and cell cultures. In animal research, dosing is usually expressed in micrograms per kilogram (µg/kg), depending on the study’s objectives and duration. In vitro experiments typically use nanomolar to micromolar concentration ranges to evaluate cellular responses. There are no established human dosing guidelines for Epithalon (50mg), as it is intended solely for laboratory research.

How should Epithalon (50mg) be stored and handled?

Epithalon (50mg) should be stored at 2–8 °C for standard laboratory handling. For long-term storage, ≤–20 °C is recommended. Protect the material from light and moisture. After reconstitution with a sterile laboratory-grade solvent, short-term storage at 2–8 °C is recommended. Avoid repeated freeze-thaw cycles, as these may affect peptide stability. The product has a shelf life of approximately 24 months when stored under the recommended conditions. Standard laboratory protective equipment should be worn during handling. Dispose of materials according to institutional biosafety guidelines.

Where can I read more research about Epithalon (50mg)?

The following peer-reviewed sources provide additional background on Epithalon research:

1. Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. Published 2025 Mar 17. doi:10.3390/ijms26062691
2. Khavinson V, Diomede F, Mironova E, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. Published 2020 Jan 30. doi:10.3390/molecules25030609
3. Caputi S, Trubiani O, Sinjari B, et al. Effect of short peptides on neuronal differentiation of stem cells. Int J Immunopathol Pharmacol. 2019;33:2058738419828613. doi:10.1177/2058738419828613
4. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. doi:10.1023/a:1025493705728
5. Anisimov VN, Khavinson VKh, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. doi:10.1023/a:1025114230714

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.