MGF IGF-1Ec (5mg)

What is MGF IGF-1Ec (5mg)?

MGF IGF-1Ec (5mg) refers to a peptide derived from the mechano growth factor (MGF) isoform of insulin-like growth factor 1 (IGF-1). MGF is produced through alternative splicing of the IGF-1 gene and is associated with cellular responses to mechanical stress in experimental models. The peptide used in research corresponds to the C-terminal fragment of the IGF-1Ec variant, which is being studied for its role in cellular growth signaling and tissue response to mechanical stress.

• Chemical Formula: C₁₂₄H₂₀₄N₄₂O₄₁S₁
• Molecular Weight: 2971.99 g/mol

What are the key features of MGF IGF-1Ec (5mg)?

• High research-grade purity (commonly ≥95%, verified analytically)
• Supplied as 5 mg lyophilized peptide in sealed vial format
• C-terminal peptide derived from the IGF-1Ec isoform
• Composed of approximately 24 amino acids
• Studied in muscle biology and cellular growth signaling research models
• Shelf life of approximately 24 months under recommended storage conditions
• For laboratory research use only

How is MGF IGF-1Ec (5mg) synthesized?

MGF IGF-1Ec (5mg) is typically produced using solid-phase peptide synthesis (SPPS), a widely used method for constructing peptides with precise amino acid sequences. This process allows researchers to replicate the C-terminal segment of the IGF-1Ec isoform, which is produced in biological systems in response to mechanical stress. After synthesis, purification is performed by high-performance liquid chromatography (HPLC) to ensure high purity. Molecular identity and mass are confirmed using mass spectrometry (MS). The purified peptide is then lyophilized to enhance stability, making it suitable for storage and transport in research laboratories.

What is MGF IGF-1Ec (5mg) being studied for? What are its possible benefits?

MGF IGF-1Ec (5mg) has been studied in laboratory research focused on cellular growth signaling and tissue responses to mechanical stress. Experimental investigations have explored its involvement in:

• Muscle regeneration research
• Cell proliferation and differentiation models
• Satellite cell activation studies
• Tissue repair and remodeling research
• Growth factor signaling pathways

In experimental systems, MGF IGF-1Ec has been studied for its potential to regulate cellular responses to mechanical stress and injury. These potential biological effects are based on experimental research rather than established therapeutic outcomes.

How does MGF IGF-1Ec (5mg) work in research studies?

In laboratory environments, MGF IGF-1Ec (5mg) is being researched for its potential role in signaling pathways associated with tissue response and cellular growth. As a splice variant of the IGF-1 gene, MGF is thought to be produced in response to mechanical stress, particularly in muscle cells. MGF IGF-1Ec may act as a signaling peptide that influences early cellular responses to tissue damage. Experimental studies have examined how it may affect satellite cell activation, protein synthesis, and cellular proliferation in muscle models. These mechanisms remain under investigation and are limited to controlled research settings.

What dosing information exists for MGF IGF-1Ec (5mg)?

Preclinical research involving MGF IGF-1Ec has been conducted primarily in cell culture systems and animal models. In vitro studies often use nanomolar to micromolar concentration ranges to investigate effects on cellular signaling and proliferation. Animal research has reported experimental dosing in microgram-per-kilogram (µg/kg) ranges, depending on the biological system and study objective. Dosing schedules vary widely across experimental protocols. There are no established human dosing guidelines for MGF IGF-1Ec (5mg), as it is intended exclusively for laboratory research use.

How should MGF IGF-1Ec (5mg) be stored and handled?

MGF IGF-1Ec (5mg) should be stored at 2–8 °C for standard laboratory handling. For long-term preservation, storage at ≤–20 °C is recommended to maintain peptide stability. The product should be protected from excessive light and moisture. After reconstitution using sterile laboratory-grade solvent, short-term storage at 2–8 °C is typically recommended. Repeated freeze–thaw cycles should be avoided, as these may affect peptide integrity. Under recommended conditions, the product has an approximate shelf life of 24 months. Standard laboratory protective equipment should be used during handling, and disposal should follow institutional biosafety procedures.

Where can I read more research about MGF IGF-1Ec (5mg)?

1. Schlegel W, Raimann A, Halbauer D, et al. Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor--a splice variant of IGF-1 within the growth plate. PLoS One. 2013;8(10):e76133. Published 2013 Oct 11. doi:10.1371/journal.pone.0076133
2. Li C, Vu K, Hazelgrove K, Kuemmerle JF. Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy. Am J Physiol Gastrointest Liver Physiol. 2015;309(11):G888-G899. doi:10.1152/ajpgi.00414.2014
3. Milingos DS, Philippou A, Armakolas A, et al. Insulinlike growth factor-1Ec (MGF) expression in eutopic and ectopic endometrium: characterization of the MGF E-peptide actions in vitro. Mol Med. 2011;17(1-2):21-28. doi:10.2119/molmed.2010.00043

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.